Design and synthesis of biphenyl and biphenyl ether inhibitors of sulfatases† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc03612g Click here for additional data file.

Design and synthesis of biphenyl and biphenyl ether inhibitors of sulfatases.

Inhibitors of sulfatase-2 are putative anticancer agents, but the discovery of potent small molecules targeting this enzyme has proved challenging. Based on molecular modelling, two series of sulfatase-2 inhibitors have been developed with biphenyl and biphenyl ether scaffolds judiciously substituted with sulfamate, carboxylate and other polar groups (e.g. amino). Inhibition of aryl sulfatase A...

Imposing control on self-assembly: rational design and synthesis of a mixed-metal, mixed-ligand coordination cage containing four types of component† †Electronic supplementary information (ESI) available: Synthesis of the cage complex; bond distances and angles around the metal ions; COSY and DOSY NMR data; and high resolution electrospray mass spectral expansion for the cage. CCDC 1425635. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5sc03526k Click here for additional data file. Click here for additional data file.

Synthesis and stabilities of peptide-based [1]rotaxanes: molecular grafting onto lasso peptide scaffolds† †Electronic supplementary information (ESI) available: Experimental procedures and analytical data of all new compounds. CCDC 1520783. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc00021a Click here for additional data file. Click here for additional data file.

Versatile telluracycle synthesis via the sequential electrophilic telluration of C(sp2)–Zn and C(sp2)–H bonds† †Electronic supplementary information (ESI) available. CCDC 1523262–1523264. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc01162h Click here for additional data file. Click here for additional data file.

Catalytic asymmetric hydroxylative dearomatization of 2-naphthols: synthesis of lacinilene derivatives† †Electronic supplementary information (ESI) available. CCDC 1536822. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc02809a Click here for additional data file. Click here for additional data file.